Cafein
Caffeine (as 60mg caffein citrate) 30mg/3ml
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1.Composition
Caffeine (as 60mg caffein citrate) 30mg/3ml
2.Dosage Form
Solution for injection
3.Indication
Indicated for the short term treatment of apnea of prematurity in infants between 28 and < 33 weeks gestational age.
4.Dosage Administration
Prior to initiation of BFS-CAFEIN (caffeine citrate), baseline serum levels of caffeine should be measured in infants previously treated with theophylline, since preterm infants metabolize theophylline to caffeine. Likewise, baseline serum levels of caffeine should be measured in infants born to mothers who consumed caffeine prior to delivery, since caffeine readily crosses the placenta.
NOTE THAT THE DOSE OF CAFFEINE BASE IS ONE-HALF THE DOSE WHEN EXPRESSED AS CAFFEINE CITRATE (e.g., 20 mg of caffeine citrate is equivalent to 10 mg of caffeine base).
Serum concentrations of caffeine may need to be monitored periodically throughout treatment to avoid toxicity. Serious toxicity has been associated with serum levels greater than 50 mg/L.
BFS-CAFEIN should be inspected visually for particulate matter and discoloration prior to administration. Vials containing discolored solution or visible particulate matter should be discarded.
