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Ingredient:
Each vial contains Glutathione sodium (reduced form) equivalent to 1200 mg Glutathione (reduced form).
Route of administration: Intramuscular injection, intravenous injection.
Pharmacodynamic:
Glutathione is a natural tripeptide present in the cells of every organ and body organization. Is the outer group of glyceraldehydes phosphate dehydrogenase and coenzyme of glyoxalase and triose dehydrogenase, participating in the activities of many enzymes and creating disulfur bonds of many protein and polypeptide hormones. Glutathione plays an important role in the tricarboxylic acid cycle and glucose metabolism. Through activation of many enzymes, glutathione can enhance carbohydrate, fat and protein metabolism; Binding to free radicals reduces the damage caused by chemotherapy and ion radiotherapy without affecting the effectiveness of treatment, especially in small bowel inflammation caused by ion radiotherapy.
Pharmacokinetics
After intravenous infusion of 2 g glutathione, total plasma glutathione concentrations increased from 17.5 +/- 13.4 mumol 1-1 (mean +/- SD) to 823 +/- 326 mumol 1-1. The volume of distribution of exogenous glutathione is 176 +/- 107 ml kg-1 and the unchanged elimination rate is 0.063 +/- 0.027 min-1 corresponding to a half-life of 14.1 +/- 9.2 minutes. Plasma cysteine increased from 8.9 +/- 3.5 mumol 1-1 to 114 +/- 45 mumol 1-1 after infusion. Despite increases in Cysteine, plasma concentrations of total cyst(e)ine (i.e. Cysteine, cystine, and mixed disulphides) are decreased. Hypothesize increased absorption of Cysteine from plasma into cells. Urinary excretion of Glutathione and cyst(e)ine increased 300-fold and 10-fold, respectively, after a 90-minute infusion.
Clinical application:
1. Used by intravenous injection
1.1 Support to reduce neurotoxicity of radiotherapy and cancer treatment chemicals including cisplastin, cyclophosphamide, oxaplatin, 5-fluorouracil, carboplatin: Inject glutathione intravenously immediately before radiotherapy and before the protocol chemotherapy of the above chemicals.
1.2 Support for treatment of mercury poisoning: Combine specific drugs to treat mercury poisoning such as 2,3-dimercaptopropan-1-sulfonate and meso-2,3-dimercaptosuccinic acid with high-dose glutathione and vitamin C infusions reduces mercury levels in the blood.
1.3 Support in the treatment of alcoholic cirrhosis, cirrhosis, viral hepatitis B, C, D and steatohepatitis: Helps improve the patient's physical condition and biochemical indicators such as bilirubin, GOT, GPT, GT as well as significantly reduced MDA and liver cell damage.
1.4 Support in the treatment of diseases related to coronary peripheral vascular disorders and hematological disorders:
- Improves hemodynamic parameters of the large and small circulatory systems, helping to prolong pain-free walking distance in patients with lower limb artery occlusion.
- Improve vasomotor response to coronary vasodilators such as acetylcholine and nitroglycerin in patients with risk factors for coronary artery disease.
- Improve anemia in dialysis patients due to chronic kidney failure: Glutathione infusion at the end of each dialysis cycle helps reduce the dose of erythropoietin by up to 50%.
1.5 Supports the treatment of subarachnoid bleeding: Helps improve symptoms of subarachnoid bleeding.
1.6 Support in the treatment of non-insulin-dependent diabetes: Helps increase insulin sensitivity in these patients.
1.7 Support in the treatment of acute pancreatitis: Glutathione may be effective in preserving organ functions from attack by chemical mediators of the inflammatory response.
2. Use by intramuscular injection
2.1 Support in the treatment of infertility in men: Glutathione intramuscular injection lasting over two months helps improve sperm morphology and movement.
3. Use by aerosol
3.1 Supportive treatment for patients with idiopathic pulmonary fibrosis or HIV/AIDS patients with respiratory diseases related to glutathione deficiency.
Contraindicated
Hypersensitivity to Glutathione.
Careful
- This medicine should be used under the supervision of medical staff in the hospital.
- The drug must be completely dissolved when injected, the solution must be clear and colorless.
Children
Infants, premature infants, children, and teenagers should use this medication with great caution, especially intramuscularly.
Old person
Appropriate dose reduction is recommended and monitoring is necessary throughout drug use.
Pregnancy and lactation period
Pregnant women: Studies have shown no evidence of impaired fertility or teratogenicity, but there have been no adequate studies of this drug in pregnant women. Therefore, caution should be exercised when using the drug for pregnant women.
Breastfeeding women: The drug may be excreted in breast milk, so care should be taken when using this drug for breastfeeding women.
Affects the ability to drive and operate machinery
No impact.
Adverse reactions (ADR)
Pain at the intramuscular injection site.
Allergic reactions (rash) may occur, but are very rare and will resolve when treatment is stopped.
Inform your doctor of any unwanted effects you encounter when using the drug.
Dosage and Administration
How to use:
(1) Intravenous injection: dissolve the drug with water for injection and add 100 ml of 0.9% sodium chloride injection, inject intravenously. Or dissolve Glutathione (reduced form) in less than 20 ml of 0.9% sodium chloride injection, slow intravenous injection.
(2) Intramuscular injection: Dissolve the drug with water for injection then inject intramuscularly.
Dosage:
1. Chemotherapy: 15 minutes before chemotherapy, Glutathione (reduced form) (1500 mg/m2) dissolved with 100 ml of 0.9% sodium chloride injection, then injected for 15 minutes. During days 2 to 5, 600 mg intramuscularly once daily.
CTX (Cyclophosphamide) treatment, immediately after CTX injection, inject Glutathione (reduced form) intravenously for 15 minutes to reduce urinary tract damage.
For Cisplatin treatment, the dose of Glutathione (reduced form) should not be greater than 35 mg/mg cisplatin to avoid affecting the effectiveness of chemotherapy.
2. Liver failure: intravenous drip or intramuscular injection.
3. Other diseases: as well as treatment of hypoxemia, the drug (1500 mg/m2) is dissolved with 100 ml of 0.9% sodium chloride injection and initially administered intravenously, until improvement, Dosage can be reduced to 300-600 mg once daily, intramuscularly for maintenance.
Mild cases: 0.3-0.6 g 1 or 2 times daily, intravenous drip or intramuscular injection.
Severe cases: 0.6-1.2 g 1 or 2 times daily, intravenous drip or intramuscular injection.
The dose may be adjusted according to the patient's age or medical condition.
Treatment duration: general treatment cycle for liver disease is 30 days, other cases depend on the disease condition.
Drug interactions
This medicine should not be used in combination with Vitamin B12, Vitamin K3, aquinone, calpanate, saratin, antihistamines, sulphonamides and economycin.
Stability
After reconstitution, the solution can be stored for 2 hours at room temperature and 8 hours at 0-50C.
Overdose
High doses of 5g glutathione used in cancer patients have not yet detected toxicity.
Possible symptoms of drug overdose: chest pain, difficulty breathing, muscle spasms; have allergic reactions such as rash, excessive itching.
Treatment: There is currently no specific antidote. Stop taking the drug immediately if there are signs of overdose; combined with active supportive treatment measures.
Storage: Cool and dry place, temperature not exceeding 300C, protected from light.
Expiry date: 36 months from date of manufacture.
Packaging: Box of 1 bottle, with instructions for use.
